A Clinical Trial of Pembrolizumab (MK-3475) Evaluating Predictive Biomarkers in Subjects with Advanced Solid Tumors (KEYNOTE 158) Tumor Types (Groups): Cohort M: Any advanced solid tumor that has failed at least one line of therapy and is TMB-H (?10 mut/Mb, F1CDx assay), excluding dMMR/MSI-H tumors. Note: For subjects to be eligible for enrollment in Group M, they must have failed at least one line of standard of care systemic therapy (ie, not treatment naïve), with the exception of CRC subjects who must have failed at least 2 lines of standard of care systemic therapy Note: SUBJECTS WILL NOT BE ELIGIBLE TO ENROLL INTO GROUP M UNLESS TMB AND MSI STATUS CAN BE ASSESSED USING TISSUE FROM THE SAME SINGLE TUMOR SPECIMEN. SUBJECTS WITH PREVIOUSLY KNOWN dMMR AND/OR MSI-H STATUS SHOULD NOT BE SCREENED FOR COHORT M.
Zielgerichtet - Therapieart: palliativ
